Efficient and High-Yielding Protocol for the Synthesis of Nitriles from Aldehydes

Abstract

An operationally simple and high-yielding procedure has been developed for the conversion of araldehydes into the corresponding nitriles using p-toluenesulfonic acid (p-TSA) (a mild catalyst) under microwave irradiation. The products are characterized by infrared spectral analysis and by comparison of the melting and boiling points with the reported values.

Keywords:

• Araldehydes
• hydroxylamine hydrochloride
• microwave irradiation
• nitriles
• p-TSA

Notes

^a All the products are known and were characterized by IR spectral analysis and comparison of their melting and boiling points with the authentic samples prepared by the reported method [Ref. 15].

^b Isolated yield.

^a Isolated yield (column chromatography).