Boric Acid–Mediated Mild and Efficient Friedel–Crafts Alkylation of Indoles with Nitro Styrenes

Abstract

An efficient method has been developed for the synthesis of indole 3-derivatives by the Friedel–Crafts alkylation of indole with nitro olefins in presence of boric acid in aqueous medium.

Keywords:

• Boric acid
• indole
• N-methyl indole
• nitro styrene
• water

ACKNOWLEDGMENTS

The authors thank CSIR-UGC for the award of a fellowship and Dr. J. S. Yadav, Director IICT, for his support and encouragement.