A Green Route for Synthesis of New 1,2-Naphthoquinomethane Acetonitriles in Water

Abstract

A series of new 2-(3-hydroxy-4-oxo-4H-naphthalen-1-ylidene) acetonitriles was prepared by the cascade Michael addition-elimination reaction of sodium 1,2-naphthoquinone-4-sulfonate with various substituted acetonitriles compounds in ethanol-water in presence of basic catalyst.

Keywords:

• Antibacterial
• cascade reaction
• 1,2-naphthoquinomethane
• water solvent

ACKNOWLEDGMENTS

The authors gratefully acknowledge the CNRS (Centre National de la Recherche Scientifique), the (Région Basse-Normandie), the University “Abou-Bekr Belkaid” of Tlemcen, and the European Union (FEDER funding) for their financial support.