Water-Mediated Strecker Reaction: An Efficient and Environmentally Friendly Approach for the Synthesis of α-Aminonitriles via a Three-Component Condensation

Abstract

The synthesis of α-aminonitriles by a direct three component Strecker reaction has been achieved in water, which is found to be an inexpensive, non-toxic and eco-friendly reaction medium for the nucleophilic addition. This protocol is effective to a wide variety of substrates with different functional groups and does not require the use any other catalyst.

Keywords:

• α-Aminonitriles
• Strecker reaction
• three-component reaction
• TMSCN
• water

Notes

^§Novel compounds (entry 21–24) are characterized by IR,¹H NMR,¹³C and LC-mass spectral analysis.

^a Products (entry 1–20) are known and compared with authentic samples [refs. 8, 9, 16–24].

^b Isolated yields.