Synthesis of Substituted Isoxazoles and Pyrazoles from α-α-Dioxoketen Dithioacetals Under Solvothermal Conditions

Abstract

Some new 3,4,5-substituted isoxazoles, 3,4,5 and 1,3,4,5-substituted pyrazoles were prepared by reaction of α,α-oxoketen dithioacetals with hydroxylamine hydrochloride; phenyl hydrazine and hydrazine hydrate respectively under solvothermal conditions involving an ecofriendly method without any environmental pollution. The yields are in the range of 71–91%. The structure of the new compounds were established upon their elemental analysis, IR, ¹H NMR, and ¹³C NMR.

Keywords:

• Isoxazoles
• α,α-oxoketen dithioacetals
• pyrazole
• solvothermal