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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 24
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Original Articles

A Highly Efficient Synthesis of Sulphonamide Derivatives in the Presence of N-Methyl-2-pyrrolidone

Yong Tan College of Chemistry and Environment Science, Hebei University, Baoding, P. R. China
,
Su Juan Wang College of Chemistry and Environment Science, Hebei University, Baoding, P. R. China
,
Yi Ting Wang College of Chemistry and Environment Science, Hebei University, Baoding, P. R. China
,
Bao Xiang Gao College of Chemistry and Environment Science, Hebei University, Baoding, P. R. China
&
Xin Wu Ba College of Chemistry and Environment Science, Hebei University, Baoding, P. R. ChinaCorrespondence[email protected]
Pages 3648-3653 | Received 19 May 2009, Published online: 09 Nov 2010
 
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Abstract

The sulphonamide derivatives are synthesized by two component condensation of alkyl bromide and sodium arylsulphonamide using N-methyl-2-pyrrolidone (NMP) as a reaction medium. This method results in high yields without the formation of unwanted side products, and expanding substrate scopes.

ACKNOWLEDGMENT

This work was supported by National Natural Science Foundation (20574016).

Notes

a Yields refer to pure isolated products.

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