Efficient Synthesis of Aryl Methyl Sulfide Derivatives Using (Methylthio)trimethylsilane as Methylthiolation Reagent

Abstract

The synthesis of various aryl methyl sulfides has been achieved by treatment of nitroarenes with a combination of (methylthio)trimethylsilane and cesium carbonate in dimethylsulfoxide. This reaction gives access to aryl methyl sulfide derivatives in high yields.

Keywords:

• Aryl methyl sulfides
• methylthiolation
• (methylthio)trimethylsilane
• nitroarenes
• nucleophilic displacement

ACKNOWLEDGMENTS

The authors are grateful to Paul Gillespie and Jeff Tilley for critical reading of this manuscript.