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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 24
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Original Articles

A Clean and Expedient Synthesis of Pyrido[1,4]oxazepino Spiropyrrolidines Through One-Pot, Three-Component [3 + 2] Cycloaddition Reaction

, &
Pages 3721-3727 | Received 15 Sep 2009, Published online: 09 Nov 2010
 

Abstract

One-pot three component synthesis of novel pyrido[1,4]-oxazepine fused spiropyrrolidines has been accomplished in good yields by 1,3-dipolar cycloaddition reaction of azomethine ylide, derived from paraformaldehyde and sarcosine with (E)-4-benzylidene-hexahydro-1H-pyrido[2,1-c][1,4]-oxazepine-3(7H)-one as dipolarophiles derived from Baylis-Hillman adducts. The effect of solvent on the [3 + 2]-cycloaddition reaction is also studied.

ACKNOWLEDGMENTS

S.K. thanks Counsil of Scientific Industrial and Research (CSIR) for Senior Research Fellowship (SRF). R.R. thanks DST-FIST for NMR facility and financial assistance.

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