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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2010 - Issue 1
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Original Articles

Lactam Coupling as a Versatile Route to Indoprofen Analogs

Keith D. Barnes Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Ping Chen Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Yingyan Chang Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Robert M. Lewis Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Christopher M. Manley Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Nicholas J. Mayhew Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Stephen H. Steffke Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Guixing Wang Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Yi Wang Medicinal Chemistry Department, AMRI, Albany, New York, USA
,
Yuh-Lin A. Yang Medicinal Chemistry Department, AMRI, Albany, New York, USA
&
John W. Lippert III Medicinal Chemistry Department, AMRI, Albany, New York, USACorrespondence[email protected]
 show all
Pages 67-72 | Received 16 Sep 2009, Published online: 14 Dec 2010
 
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Abstract

A convergent synthesis of indoprofen via a Buchwald coupling approach is reported. Using this methodology, indoprofen and a set of analogs of indoprofen were readily prepared.

ACKNOWLEDGMENTS

The authors acknowledge Drs. Jill Heemskerk (National Institute of Neurological Disorders and Stroke), John M. McCall (PharMac LLC), Sabina Robinson (Science Applications International Corporation), Amelie Gubitz (National Institute of Neurological Disorders and Stroke), and James A. Romano Jr. (Science Applications International Corporation) for their advice, direction, and support on this project. This project has been funded in whole or in part with federal funds from the National Institute of Neurological Disorders and Stroke, National Institute of Health, under Contract No. N01-NS-3-2356.

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