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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2010 - Issue 1
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Original Articles

Synthesis and Characterization of Potential Impurities of Carvedilol, an Antihypertensive Drug

, , , , &
Pages 85-93 | Received 05 Sep 2009, Published online: 14 Dec 2010
 

Abstract

Carvedilol (Coreg) is a nonselective β-adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities.

ACKNOWLEDGMENTS

The authors are grateful to colleagues in the Analytical Research and Development department and the management of Srini Pharmaceuticals Ltd. for providing the necessary support.

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