Abstract
Addition of an isocyanide to an iminium ion intermediate that forms from the reaction between a heteroarylcarbaldehyde and a secondary amine leads to formation of sterically congested 2-(heteroaryl)acetamide derivatives in the presence of silica gel at room temperature. The structures of the products were deduced from their Citation 1 H NMR, Citation 13 C NMR, and infrared spectra and mass spectrometry.
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ACKNOWLEDGMENT
This work was supported by the Iranian National Science Foundation.