Copper(I)-Catalyzed Cycloaddition of Methyl O-Propargylpodocarpate and Azides at Room Temperature

Abstract

Copper iodide was employed as an efficient catalyst for the synthesis of 1,2,3-triazole derivatives of podocarpic acid at room temperature through “click” chemistry cycloaddition reactions of methyl O-propargylpodocarpate and propargyl O-propargylpodocarpate with azides.

Keywords:

• Azides
• copper(I) iodide
• methyl O-propargylpodocarpate
• podocarpic acid derivatives
• 1,2,3-triazoles

ACKNOWLEDGMENTS

This work was supported by the Chemistry Department of the University of Central Florida. The authors thank the Nebraska Center for Mass Spectrometry for providing the MS data.