Synthesis of New Spiro[1,4,2-dioxazole-5,3′-indolin]-2′-one by 1,3-Dipolar Cycloaddition

Abstract

Novel spiro[1,4,2-dioxazole-5,3′-indolin]-2′-one derivatives were synthesized by 1,3-dipolar cycloaddition reactions of the isatin derivative with aryl nitrile oxide. The cycloadducts were characterized by spectral data including ¹H NMR, ¹³C NMR, infrared, mass spectra, and elementary analysis.

Keywords:

• 1,4,2-Dioxazole
• 1,3-dipolar cycloaddition
• isatin
• isoxazole
• isoxazoline

ACKNOWLEDGMENTS

The authors acknowledge the financial support provided by the Ministry ESRSFC of the Moroccan Government (Pôle de Compétences Pharmacochimie) and IUT Béthune.