Abstract
An efficient method for preparation of the arylaminotetrazoles derivatives is reported using aluminium chloride as an effective Lewis acid. Generally, 5-arylamino-1H-tetrazole isomer can be obtained from arylcyanamides carrying electron-withdrawing substituents on the aryl ring. As the electropositivity of the substituent is increased, the product is shifted toward the formation of 1-aryl-5-amino-1H-tetrazole isomer.
ACKNOWLEDGMENT
The authors are thankful to the Bu-Ali Sina University for the partial support of this work.
Notes
a Yield refers to pure isolated products.
a Isolated yield.
b Under solvent-free and thermal conditions at 80 °C.
c Glacial acetic acid as both solvent and proton donor source.
d Room temperature.