Synthesis of N-Boc-C1 Vinyl Tetrahydroisoquinoline via Zn-Mediated Intramolecular Cyclization of N-Boc Protected Iodo Acetonide

Abstract

The Zn-mediated elimination of N-Boc protected iodo acetonide undergoes intramolecular cyclization to afford N-Boc-C1 vinyl tetrahydroisoquinoline in good yield.

Keywords:

• Heck reaction
• intramolecular cyclization
• iodo acetonide
• N-Boc-C1-vinyl
• tetrahydroisoquinoline
• zinc

ACKNOWLEDGMENTS

R. T. S. is thankful to the Council for Scientific and Industrial Research, New Delhi, for a senior research fellowship. We are grateful to the Department of Science and Technology, New Delhi, and Board of College and University Development (BCUD) and Shimadzu Analytical Centre, University of Pune, for financial assistance and spectral analysis, respectively.