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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 16
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Original Articles

Room-Temperature Synthesis of Diindolylmethanes Using Silica-Supported Sulfuric Acid as a Reusable Catalyst Under Solvent-Free Conditions

, , &
Pages 2446-2454 | Received 05 Aug 2009, Published online: 14 Jun 2011
 

Abstract

Efficient electrophilic substitution reactions of indoles with various aromatic and aliphatic aldehydes were carried out using a catalytic amount of H2SO4 · SiO2 under solvent-free conditions to afford the corresponding bis(indolyl)methanes in excellent yields.

Notes

a Isolated yields after column chromatography.

a Reactions performed with 1.0 mmol of 4-nitrobenzaldehyde, 2 mmol of indole, and 50 mg of H2SO4 · SiO2 mixed for 8 min under solvent-free conditions at room temperature.

b Isolated yields after purification.

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