Ammonium Chloride–Catalyzed One-Pot Synthesis of Tetrahydrobenzo[α]xanthen-11-one Derivatives Under Solvent-Free Conditions

Abstract

A one-pot, multicomponent reaction of aldehydes, dimedone, and β-naphthols is described for the preparation of 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[α]xanthen-11-one derivatives using ammonium chloride as a mild, inexpensive, and environmentally benign catalyst under solvent-free conditions. Different types of aldehyde and β-naphthol derivatives are used in the reaction, and in all cases the products were synthesized successfully.

Graphical Abstract

Keywords:

• Ammonium chloride
• multicomponent
• one pot
• solvent-free
• xanthene

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from the Research Council of Arak University.

Notes

^aIsolated yields.

^aIsolated yields.

^aIsolated yields.