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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 19
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Original Articles

Microwave Irradiation–Assisted Amination of 2-Chloropyridine Derivatives with Amide Solvents

Abdelouahid Samadi Laboratorio de Radicales Libres y Química Computacional, Madrid, SpainCorrespondence[email protected]
,
Daniel Silva iMEd. UL, Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
,
Mourad Chioua Laboratorio de Radicales Libres y Química Computacional, Madrid, Spain
,
Maria do Carmo Carreiras iMEd. UL, Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
&
José Marco-Contelles Laboratorio de Radicales Libres y Química Computacional, Madrid, SpainCorrespondence[email protected]
Pages 2859-2869 | Received 07 May 2010, Published online: 29 Jun 2011
 
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Abstract

A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,N-dimethyl)amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts.

ACKNOWLEDGMENTS

The present work has been supported by MEC Grant SAF2006-08764-C02-01, Comunidad de Madrid (S/SAL-0275-2006), Instituto de Salud Carlos III [RETIC RENEVAS (RD06/0026/1002)], and AECI (A/07492/07). A. S. thanks CSCI for the JAE-doc contract. M. C. thanks the Instituto de Salud Carlos III (Ministerio de Salud y Consumo) for a postdoctoral fellowship.

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