Synthetic Approach to 4a-Methyltetrahydrofluorene-Type Diterpenoids via an Aromatic Oxidation of Phenol Derivatives

Abstract

An intramolecular aromatic oxidation of a phenolic compound with a hypervalent iodine reagent afforded the coupling product, in which the coupling took place at the para-position of the methoxy goup of the starting material instead of the desired para-position of the isopropenyl group, unfortunately.

Keywords:

• Aromatic oxidation
• dichroanone
• diterpenoid
• hypervalent iodine reagent
• 4a-methyltetrahydrofluorene skeleton

ACKNOWLEDGMENTS

This research was supported financially in part by a grant for the Open Research Center Project and a grant-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.