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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 23
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Original Articles

Disodium Hydrogen Phosphate as an Efficient and Cheap Catalyst for the Synthesis of 2-Aminochromenes

, , &
Pages 3477-3484 | Received 07 Oct 2009, Published online: 04 Aug 2011
 

Abstract

An efficient and convenient method for the synthesis of 2-aminochromene by the one-pot, three-component reaction of an aromatic aldehyde, malononitrile, and α- or β-naphthol in the presence of a catalytic amount of disodium hydrogen phosphate under solvent-free conditions is described.

ACKNOWLEDGMENTS

We are grateful for financial support from the National Natural Science Foundation of China (20872025 and 21072042), the Natural Science Foundation of Hebei Province (B2011205031), and the Research Foundation for Undergraduate Scientific and Technological Innovation Project (0911105004).

Notes

a Reaction condition: 4-chlorobenzaldehyde (1 mmol), malononitrile (1 mmol), and α-naphthol (1 mmol), catalyst (10 mmol%), 120 °C.

b Yields refer to isolated pure products.

a Reaction conditions: 4-chlorobenzaldehyde (1 mmol), malononitrile (1 mmol), and α-naphthol (1 mmol).

b Yields are related to isolated pure products.

a Isolated yield.

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