Efficient Synthesis of Bis(heterocyclyl)methanes

Abstract

The reaction of pyrrole/furan aldehyde with Grignard reagent and pyrrole/N-methyl pyrrole in sequence allows efficient synthesis of a number of meso-elaborated bis(heterocyclyl)methanes, which are otherwise difficult to obtain through a direct aldehyde condensation route.

Keywords:

• Bis(heterocyclyl)methane
• dipyrromethane
• Grignard reagent
• novel porphyrinoid

ACKNOWLEDGMENT

This work was supported by financial assistance from the Department of Science and Technology (SR/S1/OC-27/2009).

Notes

^a Isolated yield.

^b Yields in parentheses refer to the use of 2.0 equiv of 3.