Mild and Efficient Synthesis of N¹,N⁵,N¹⁰-Tri-tert-butoxycarbonyl Spermine

Abstract

This article describes a mild and efficient synthesis of N¹ ,N⁵ ,N¹⁰ -tri-tert-butoxycarbonyl spermine from putrescine, with a 41% overall yield. The key steps include a Michael addition and Raney nickel (W-2) reduction. The advantages of this synthesis include a simple procedure, mild conditions, and good yields.

GRAPHICAL ABSTRACT

Keywords:

• Michael addition
• Raney nickel (W-2) reduction
• synthesis
• N ¹,N ⁵,N ¹⁰-tri-Boc spermine

ACKNOWLEDGMENTS

We gratefully acknowledge the financial support for New Century Excellent Talents in University (NCET). We also thank the Laboratory of Organic Functional Molecules and the Sino-French Institute of ECNU for support.