Abstract
Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of β-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst.
GRAPHICAL ABSTRACT
![](/cms/asset/9c0a1602-d417-4af5-96d5-dd536cfebc10/lsyc_a_525335_o_uf0001.gif)
ACKNOWLEDGMENTS
K. S. R. Acknowledges the University Grants Commission (phase 2) vide No. F. 540/10/2004-05 (SAP II) and the Department of Science and Technology–Funding for Infrastructure in Science and Technology program.
Notes
a Yields refer to those of pure isolated products characterized by IR, 1H NMR, LCMS, and elementary analysis.