Abstract
A large scale synthesis of valdecoxib 1 is described. Our work features potential application of [3 + 2]-dipolar cycloaddition involving enamine and in situ–generated nitrile oxide derivatives.
GRAPHICAL ABSTRACT
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ACKNOWLEDGMENTS
The authors thank the management of Dr. Reddy's Laboratories Ltd. for supporting this work. Cooperation from colleagues in the Research and Development Department and Analytical Research and Development Department is also acknowledged.
Notes
Dr. Reddy's Communication No. IPM-00206.