Glycerin and CeCl₃ · 7H₂O: A New and Efficient Recyclable Reaction Medium for the Synthesis of Quinoxalines

Abstract

An efficient and environmentally benign process for the synthesis of quinoxalines has been developed using glycerine–cerium chloride as a reaction medium. This method is applicable to a variety of diketones and 1,2-phenylenediamines to afford the corresponding quinoxaline derivatives in excellent yields. The reaction medium was recovered and reused for further reactions without any problem.

GRAPHICAL ABSTRACT

Keywords:

• Cecl₃ · 7H₂O
• diketones
• glycerine
• ortho-phenylenediamines
• quinoxalines

ACKNOWLEDGMENT

J. K. K. is thankful to the University Grants Commission, New Delhi, for providing a fellowship.

Notes

^a All the products were identified by their ¹H NMR, IR, and mass.

^b Yields were isolated and not optimized.