Abstract
A highly efficient method for the synthesis of 1,4-phenylenedithioureas promoted by microwave irridiation is reported. It is based on the nucleophilic addition reaction of 1,4-phenylenediisothiocyanate to aromatic amines under solvent- and catalyst-free conditions. The reaction has the advantages of short reaction time, good yields, and environmental acceptability.
GRAPHICAL ABSTRACT
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Notes
a The power of MWI was 300 W.
b Isolated yield based on 1,4-phenylenediisothiocyanate.
a Materials were heated up to 60 °C in organic solvents.
b Isolated yield based on 1,4-phenylenediisothiocyanate.
a The power of MWI was 300 W at 60 °C.
b Isolated yield based on 1,4-phenylenediisothiocyanate.