Efficient One-Pot Synthesis of β-Unsaturated Isoxazol-5-ones and Pyrazol-5-ones Under Ultrasonic Irradiation

Abstract

4-Arylmethylidene-3-isopropylisoxazol-5-ones and 4-arylmethylidene-1-phenyl-3-isopropylpyrazol-5-ones have been prepared from the reactions of hydroxylamine and phenylhydrazine with methyl 4-methyl-3-oxovalerate and aromatic aldehydes in an aqueous medium at room temperature in the presence of pyridine under ultrasonic irradiation. The simple and facile method produced products in good yields.

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GRAPHICAL ABSTRACT

Keywords:

• Isoxazol-5-one
• 4-methyl-3-oxovalerate
• one-pot synthesis
• pyrazol-5-one
• three-component reaction

ACKNOWLEDGMENT

This research was supported by the Natural Science Foundation of Xinjiang Science Technology Agency (No. 2009211A02).

Notes

^a Yields of the isolated products.