Abstract
Dihydroartemisinin can be converted to its ether derivatives in good yields by reaction with different alcohols in the presence of a catalytic amount of dodecatungstophosphoric acid hydrate. Easy handling, trouble-free workup by filtration, excellent yields, and very short reaction times are some of the highlights of this protocol.
GRAPHICAL ABSTRACT
![](/cms/asset/ab3535e7-7364-459f-9d2f-90491c57a621/lsyc_a_538887_o_uf0001.gif)
ACKNOWLEDGMENTS
SAIF, North Eastern Hill University (NEHU), is acknowledged for recording NMR, mass, and elemental analysis. Financial help from the University Grants Commission, SAP, Department of Chemistry, NEHU, is also gratefully acknowledged.
Notes
a 10 mol% of the catalyst was used.
b Unreacted starting materials were recovered.
a Conditions: dihydroartemisinin/alcohol/H3PW12O40.xH2O = 1:1.25:0.05 CH2Cl2, rt.
b Isolated yield.