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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 9
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Original Articles

Synthesis of (±)-Bimatoprost

M. Harikrishna Aptuit Laurus Private Limited, ICICI Knowledge Park, Hyderabad, India
,
H. Rama Mohan Aptuit Laurus Private Limited, ICICI Knowledge Park, Hyderabad, IndiaCorrespondence[email protected]
,
P. K. Dubey Department of Chemistry, College of Engineering, J N T University, Hyderabad, India
,
M. Shankar Aptuit Laurus Private Limited, ICICI Knowledge Park, Hyderabad, India
&
Gottumukkala V. Subbaraju Aptuit Laurus Private Limited, ICICI Knowledge Park, Hyderabad, India
Pages 1288-1305 | Received 15 Jul 2010, Published online: 11 Jan 2012
 
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Abstract

A general synthetic approach has been developed for the synthesis of a key intermediate (6) that can be elaborated into several ophthalmic prostaglandins and their derivatives. Using these strategy, we have obtained (±)-bimatoprost (1) and its analog, (±)-homobimatoprost (5).

GRAPHICAL ABSTRACT

ACKNOWLEDGMENT

The authors thank C. Satyanarayana, CEO, Aptuit Laurus Private Ltd., for his encouragement.

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