Abstract
A synthetic utility of hypervalent iodine reagent, (diacetoxyiodo)benzene, with a catalytic amount of sodium azide for oxidation of benzylic C-H to corresponding ketone compounds is described. The advantage of this protocol is characterized by mild reaction conditions and shorter reaction time to obtain moderate to good yields.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENT
K. A. S. thanks the Council of Scientific and Industrial Research (CSIR, New Delhi) for providing a junior research fellowship.
Notes
a Reaction conditions: substrate (5.91 mmol), (diacetoxyiodo)benzene (2 equiv), and NaN3 (0.1 equiv) in CH3CN/H2O (10 mL).
b Isolated yields after column chromatography and structures were confirmed by comparison of IR and 1H NMR with authentic materials.
c No reaction.