PANI-HBF₄: A Reusable Polymer-Based Solid Acid Catalyst for Three-Component, One-Pot Synthesis of 3-Substituted Amino Methyl Indoles Under Solvent-Free Conditions

Abstract

A simple, fast, efficient, high-yielding, and green process is developed for one-pot, three-component synthesis of 3-substituted amino methyl indoles under solvent-free conditions using polyaniline salt as polymer-based reusable solid acid catalyst at room temperature. The advantages of polyaniline salt catalyst are ease of synthesis and handling, low cost, versatality, and recyclability.

GRAPHICAL ABSTRACT

Keywords:

• Multicomponent reaction
• polyaniline salt catalyst
• reusable catalyst
• 3-substituted amino methyl indoles

ACKNOWLEDGMENTS

The authors thank Dr. J. S. Yadav, director, Indian Institute of Chemical Technology, for facilities under the Projects MLP0007 and MLP0013 and encouragement. CLD thanks the Council of Scientific and Industrial Research, New Delhi, for a research fellowship.

Notes

^a With respect to aldehyde.

^b Isolated yields.