Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent

Abstract

A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents at an aryl moiety for structure–activity relationships (SAR), as well as a large quantity of KRIBB3 for in vivo studies.

GRAPHICAL ABSTRACT

Keywords:

• Anticancer
• antimigratory
• cyclization
• isoxazole

ACKNOWLEDGMENT

This research was supported by a grant from the KRIBB Research Initiative Program.