ZnO as an Effective and Reusable Heterogeneous Catalyst for the Synthesis of Arylaminotetrazoles

Abstract

ZnO is an effective heterogeneous catalyst for the reaction between arylcyanamides with sodium azide to synthesize the arylaminotetrazoles in good yields. This method has advantages of good yields, simple methodology, short reaction times, and easy workup. Furthermore, the catalyst can subsequently be reused for several times without any significant loss of activity.

GRAPHICAL ABSTRACT

Keywords:

• 5-Arylamino-1H-tetrazole
• 1-aryl-5-amino-1H-tetrazole
• arylcyanamide
• heterogeneous catalyst
• ZnO

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from Bu-Ali Sina University, Hamedan, Iran.

Notes

^a Yield refers to the pure isolated products.

^b Yield after the third cycle.

^a Isolated yield.

^b Under solvent-free and thermal conditions at 80 °C.

^c Glacial acetic acid as a solvent and a proton donor source.

^d Room temperature.