Abstract
Direct conversion of aldehyde sodium bisulfites to the corresponding nitriles can be easily performed by the reaction of an aldehyde sodium bisulfites with a slight execss of hydroxylamine hydrochloride in refluxing toluene and in the presence of 1.0 equivalents of pyridine as catalyst.
GRAPHICAL ABSTRACT
Notes
a The products were characterized by comparison of their mp or bp, TLC, IR, and 1H NMR data with those of authentic samples.
b Yields of pure compounds after distillation or recrystallization.
a Reaction conditions: phenylacetaldehyde sodium bisulfite (10 mmol), hydroxylamine hydrochloride (11 mmol), 12 h.
b Isolated yield.