Abstract
The self-assembled organocatalyst of cinchona alkaloid derivatives and amino acids has been applied to a direct asymmetric vinylogous Michael addition of α,α-dicyanoolefins to nitroolefins; the corresponding products could be obtained in moderate to good yields and enantioselectivities.
GRAPHICAL ABSTRACT
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Notes
a The reaction was carried out on a 0.5-mmol scale.
b Determined by chiral HPLC analysis (Chiralcel AS).
a The reaction was carried out on a 0.5-mmol scale in THF at rt.
b Isolated yields.
c Determined by chiral HPLC analysis.
d All the products are characterized by 1HNMR, 13C NMR, FTIR, and mass spectrometry, and the absolute configurations of products were assigned by comparison with optical rotation and/or retention time on chiral HPLC with the literature value.[3d,3f]