Microwave-Assisted Efficient and Green Synthesis of Hydroxyxanthone in Water

Abstract

An efficient and green procedure has been developed for the synthesis of hydroxyxanthones from substituted 2,2′-dihydroxybenzophenone precursors via microwave-assisted base-catalyzed cyclization in water. This method provides excellent yields of products in a short time, making it a useful strategy for the synthesis of structurally diverse hydroxyxanthones.

GRAPHICAL ABSTRACT

Keywords:

• Green synthesis
• hydroxyxanthones
• microwave
• water

Notes

^a The progress of the reaction was monitored by TLC.

^b Isolated yield.

^a The progress of the reaction was monitored by TLC.

^b Isolated yields.

^a Run using P = 150 W.

^b Isolated yields.

^c All the hydroxyxanthones were characterized by ¹ H NMR, ¹³ C NMR, IR, EI-MS, and HRESIMS (see Experimental section).