Catalyst-Free, One-Pot, Expeditious Synthesis of Aminoalkylnaphthols at Room Temperature

Abstract

Aminoalkylnaphthols possess several biological and catalytic activities. A methodology has been developed for the multicomponent one-pot synthesis of aminoalkylnaphthols in dichloromethane under catalyst-free conditions at room temperature. The present approach possesses several advantages such as excellent yields, quick reaction time, mild reaction conditions, and very easy purification processes. Thirteen new compounds in addition to six known compounds have been synthesized by this methodology.

GRAPHICAL ABSTRACT

Keywords:

• Aminoalkylnaphthols
• catalyst-free
• dichloromethane
• one-pot synthesis
• room temperature

ACKNOWLEDGMENTS

One of the authors (S. R.) thanks the Council of Scientific and Industrial Research, New Delhi, for his fellowship SRF. We thank the CAS Instrumentation Facility, Department of Chemistry, University of Calcutta, for spectral data. We also acknowledge a grant received from the University Grants Commission for Major Project F. No. 37-398/2009 (SR).