Abstract
A series of triazolyl methoxyphenyl 1,8-dioxo-decahydroacridine derivatives has been prepared in a one-pot, pseudo-five-component reaction of aromatic propargylated aldehydes, various azides, dimedone, and a variety of amines in the presence of Cu(OAc)2/sodium ascorbate and 1-methylimidazolium trifluoroacetate ([Hmim]TFA) as the catalyst in good yields.
GRAPHICAL ABSTRACT
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ACKNOWLEDGMENTS
We gratefully acknowledge financial support from the Research Council of Shahid Beheshti University and the Catalyst Center of Excellence (CCE).
Notes
a Reaction conditions: propargylated aldehyde 1a (1 mmol), 4-nitrophenyl azide 2a (1 mmol), 3-nitroaniline 3b (1.2 mmol), and dimedone 4 (2 mmol).
b In all reactions the conditions were optimized for a 100% conversion.
c The reactions were run in the presence of 10 mol% of catalyst.
d Isolated yield based on 1a.
e The reaction was run under neat conditions.
f Only compound 6 was isolated.
a Isolated yield.