Abstract
One-pot synthesis of 3,4-diaryl substituted 2(5H)-furanones was established and its commercial application has been demonstrated by accomplishing total synthesis of rofecoxib, under mild reaction conditions, with good yields and purity.
GRAPHICAL ABSTRACT
![](/cms/asset/a8127c63-5646-4ed1-aca5-bd8494110af9/lsyc_a_577923_o_uf0001.gif)
ACKNOWLEDGMENTS
We are grateful to the management of the Zydus Group for encouragement. We thank the analytical department for providing analytical support.
Notes
a Reaction completion time monitored with TLC.
b Purity of compounds analyzed by HPLC at λ max 220 nm using column ODS C-18, 150 cm × 4.6 mm × 4 µm on AGILENT 1100.
ZRC Communication No. 327 (part of A. Argade's PhD work).