Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 21
309
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Palladium-Catalyzed 8-Exo Trig Intramolecular Heck Reaction Under Microwave Irradiation in the Presence of Basic Alumina

, , , , , , , , & show all
Pages 3166-3176 | Received 31 Jan 2011, Published online: 17 Aug 2012
 

Abstract

The Heck cross-coupling reaction has been employed for efficient conversion of quinolines to benzoxocinoquinoline through a microwave-assisted palladium-catalyzed intramolecular cyclization in the presence of basic alumina.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

We thank the Council of Scientific and Industrial Research (CSIR), New Delhi, for financial support in the form of fellowships to P. Saha, S. Mondal, A. Hazra, S. Naskar, A. Maity, K. B. Sahu, and R. Paira. We are also thankful to B. Achari, emeritus scientist, CSIR, for suggestions and encouragement. Our special thanks go to B. C. Ranu of Indian Association for the Cultivation of Science (IACS), Kolkata, for his generous cooperation in utilizing the microwave instrument.

Notes

a All the studies were performed by using 4a, Pd(OAc)2 catalyst under microwave irradiation at 250 W.

b Isolated yield.

c No reaction.

a Reaction conditions: basic alumina (250 mg), Heck precursor (1 equiv.), Pd(OAc)2 (6 mol%), and TBAB, under microwave irradiation (250 W), reaction time 12 min, temperature 120 °C.

b Isolated yield. The products were characterized by MS and 1H and 13C NMR spectroscopy.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.