Synthesis, Characterization, and Antimicrobial Evaluation of Quinoline-Oxadiazole–Based Azetidinone Derivatives

Abstract

A series of 3-chloro-1-(aryl)-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-4-ethyl-azetidin-2-ones (5a–l) have been synthesized and characterized by IR, ¹H NMR, and¹³C NMR. Synthesized compounds were screened for their antimicrobial activity against different strains of bacteria (E. coli, P. aeruginosa, S. aureus, S. pyogenes, C. albicans, A. niger, and A. clavatus). On the basis of statistical analysis, it has been observed that compounds had significant correlations.

GRAPHICAL ABSTRACT

Keywords:

• Antimicrobial activity of quinoline
• quinoline-oxadiazole-azetidinone
• quinoline-oxadiazole-azetidinone heterocycle

Notes

SD˭Standard deviation *p ≤ 0.0001.