Abstract
We report here the synthesis of nitropyrazoles in good to excellent yields from iodopyrazoles over silica–sulfuric acid catalyst for the first time. The present procedure require less acid, offers a simplified workup procedure, and may be applied for the nitration of a wide variety of iodoazoles in drug and pharmaceutical industries.
GRAPHICAL ABSTRACT
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ACKNOWLEDGMENT
The Defence Research Development Organisation (DRDO), India, is gratefully acknowledged for financial support through the Advanced Centre of Research in High Energy Materials (ACRHEM).