Cost-Effective and Large-Scale Synthesis of 16:0 Lysophosphatidic Acid

Abstract

Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention because of its role in neoplastic diseases. Popularity of the compound has necessitated the use of large quantities of the phospholipid for in vivo and in vitro testing, but methods for generating LPA require the use of costly procedures, namely phosphoramidite coupling reagents. Additionally there has been no reported large-scale synthesis of LPA. In the present study we report the cost-effective and large-scale synthesis of 16:0 LPA.

GRAPHICAL ABSTRACT

Keywords:

• Autotaxin
• large-scale synthesis
• lysophosphatidic acid

ACKNOWLEDGMENT

This work is supported by NIH Grants R01 GM052722 and R01 GM067958.