Highly Efficient and Selective Deprotection Method for Prenyl, Geranyl, and Phytyl Ethers and Esters Using Borontrifluoride–Etherate

Abstract

An efficient, simple, and practical method has been developed for the deprotection of prenyl, geranyl, and phytyl ethers and esters of aromatic and aliphatic compounds using borontrifluoride–etherate (BF₃ · OEt₂) at room temperature in good to excellent yields for the first time.

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GRAPHICAL ABSTRACT

Keywords:

• BF₃ · OEt₂
• deprotection
• geranylether
• prenylester
• prenylether

ACKNOWLEDGMENTS

The authors are thankful to Dr. T. K. Chakraborty, director, CDRI, for support on the synthesis of bioactive compounds, the SAIF Division of CDRI for spectral data, and the Department of Science and Technology and the Council of Scientific and Industrial Research, New Delhi, for financial support. This is CDRI manuscript no. 8057.