Contiguous Generation of Quaternary and Tertiary Stereocenters: One-Pot Synthesis of Chroman-Fused S-Proline-Derived Chiral Oxazepinones

Abstract

A new class of chroman-fused S-proline-derived chiral oxazepinones has been synthesized in one pot through contiguous generation of quaternary and tertiary stereocenters.

GRAPHICAL ABSTRACT

Keywords:

• Chromans
• hydrogen peroxide
• oxazepinone
• α,β-unsaturated amide

ACKNOWLEDGMENTS

This research project was supported by Department of Science and Technology, New Delhi, India, in the form of a grant. Ritesh, Maloy, and Sankalan thank the Council of Scientific and Industrial Research for research fellowships. This is CDRI Communication No. 7345.