Novel One-Pot Synthesis of Aziridines Carrying Sydnone Moiety and Their Biological Studies

Abstract

A novel series of 5-(3-arylsydnon-4-yl)-7-aryl-1,4-diazabicyclo[4,1,0]hept-4-enes 3a–l were prepared in a one-pot synthesis by the reaction of 2,3-dibromo-1-(3-arylsydnon-4-yl)-3-arylpropan-1-one 1a–l and 1,2-diaminoethane. The newly synthesized compounds were screened for their antibacterial and antifungal activity.

GRAPHICAL ABSTRACT

Keywords:

• Aziridine
• biological activity
• one-pot synthesis
• sydnone derivatives

ACKNOWLEDGMENTS

The authors thank the head, RSIC, Chandigarh, and CDRI, Lucknow, for spectral and analytical data.

Notes

Notes. Diameter of the cup, 5 mm; amount of the sample used, 25 µg/cup; and solvent control, dimethyl formamide.

^a Ciprofloxacin used as standard.

^b Ciclopiroxolamine used as standard.