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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 3
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Original Articles

Alternative Synthesis of Valganciclovir Hydrochloride

Ganta Madhusudhan Reddy Research and Development, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, IndiaCorrespondence[email protected] ; [email protected]
,
V. V. N. K. V. Prasada Raju Research and Development, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, India
,
Kisara Satyanarayana Research and Development, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, India
,
Vedantham Ravindra Research and Development, Dr. Reddy's Laboratories Ltd., Bachupally, Qutubullapur, India
&
G. Venkateshwarlu Department of Chemistry, Osmania University, Hyderabad, India
Pages 425-430 | Received 27 Apr 2011, Published online: 02 Nov 2012
 
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Abstract

Synthesis of valganciclovir 1, a potent anticytomegalovirus (CMV) prodrug of ganciclovir 2, is described. The synthetic procedure involves protection–deprotection and reductive dehalogenation.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

We greatly appreciate the supportive environment encouraged at Dr. Reddy's Laboratories Ltd. We are thankful to the Intellectual Property Management (IPM) and NMR Groups of Dr. Reddy's Research Foundation and the analytical group of Integrated Product Development Organization (IPDO) for their magnanimous support.

Notes

Communication No. IPDO-IPM-00239.

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