Synthesis of Substituted Pyrimidinones Catalyzed by Boric Acid and Glycerol in Aqueous Medium

Abstract

An expeditious one-pot synthesis of substituted pyrimidinone derivatives with aromatic aldehydes, cyclopentanone, and urea (or thiourea) was developed with boric acid (10 mol%) and glycerol (0.1 mL) in aqueous medium at 45–50 °C. The methodology is simple, highly efficient, and high yielding. The idea behind this methodology is that boric acid, being a weak acid, behaves as a strong acid in presence of glycerol in aqueous medium.

GRAPHICAL ABSTRACT

Keywords:

• Aqueous medium
• boric acid
• glycerol
• substituted pyrimidinone derivatives

ACKNOWLEDGMENTS

We thank the CAS Instrumentation Facility, University of Calcutta, for spectral data. We also acknowledge a grant received from the University Grants Commission Major Project, F. No. 37-398/2009.