Abstract
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
This work was supported by Merck Frosst Centre for Therapeutic Research and Natural Sciences and Engineering Research Council of Canada (NSERC). K. J. thanks NSERC for a postgraduate scholarship (CGS M). Karine Villeneuve and Avila De Sousa are thanked for preliminary experiments.
Notes
a Isolated yield after column chromatography.
b 20 equivalent of MeOH was used.
c 7-Oxabenzonorbornadiene 1a was recovered (22–91%).
d The reaction mixture was stirred for 4 h.
e The reaction mixture was stirred for 6 h.
a Isolated yield after column chromatography.
b Yields in brackets are the amount of the corresponding naphthol isomerization product isolated.
c Some 7-oxabenzonorbornadiene was recovered.
d The reaction was run at 80 °C.
e Decomposition of 7-oxabenzonorbornadiene 1i was observed.