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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 43, 2013 - Issue 11
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Original Articles

One-Pot and Solvent-Free Synthesis of 1,4-Dihydropyridines and 3,4-Dihydropyrimidine-2-ones Using New Synthetic Recyclable Catalyst via Biginelli and Hantzsch Reactions

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Pages 1477-1483 | Received 14 Sep 2011, Published online: 06 Mar 2013
 

Abstract

Pyridine dicarboxylic acid guanidine–cobalt complex (PDAG-Co) (3) catalyzes one-pot, three-component coupling of aldehydes, β-dicarbonyl compounds, and ammonium acetate to afford the corresponding 1,4-dihydropyridines (1,4-DHPs) via Hantzsch reaction. 3,4-Dihydropyrimidine-2-ones (3,4-DHPMs) and their sulfur analogs are also synthesized under the same conditions via Biginelli condensation protocol. The catalyst is reusable at least five times, highly efficient, easily prepared, and used under mild reaction conditions.

Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view free supplemental file.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

We gratefully acknowledge Robabeh Alizadeh (University of Damghan, Faculty of Chemistry) for her comments and providing the ORTEP of crystals of catayst PDAG-Co (3). We also acknowledge Ali Akbar Agah, who prepared the catalysts whenever we needed to run the reactions. He is passed away and unfortunately no longer with us due to a sad accident.

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